Six shacks were destroyed by fire in Lydia Mzamane Road, Tambo Village in Manenberg last night.
Five firefighting appliances, a rescue vehicle and a total of 21 staff members were dispatched to the scene just after 9:30pm.
The fire was contained and subsequently extinguished at 10:58pm.
A total of 18 people have been affected. The informal settlement department will provide starter kits for the residents to rebuild.
No injuries were reported.
The cause of the fire remains unknown.